U.R. Muller D.V. Nicolau (Eds.)
Microarray Technology and Its Applications
With 123 Figures Including 16 Color Plates
Microarray Technology and Its Applications
With 123 Figures Including 16 Color Plates
کتاب تکنولوژی microarray و کاربردهای آن، به معرفی این تکنولوژی و کاربردهای آن با 4 سرفصل که در زیر آمده است می پردازد. فهرست مطالب این کتاب به شرح زیر می باشد:
Part I General Microarray Technologies
1 Array Formats Ralph R. Martel, Matthew P. Rounseville, Ihab W. Botros, Bruce E. Seligmann
1.1 Introduction
1 Array Formats Ralph R. Martel, Matthew P. Rounseville, Ihab W. Botros, Bruce E. Seligmann
1.1 Introduction
1.2 Reasons toUseArrays
1.3 Arrays for Nucleic AcidAnalysis
1.4 ProteinArrays
1.5 The ArrayPlate
1.6 Conclusion
TM
2 Biomolecules and Cells on Surfaces – Fundamental Concepts Kristi L. Hanson, Luisa Filipponi, Dan V. Nicolau
2.1 Introduction
2.2 Types of Immobilization
2.3 DNA Immobilization on Surfaces
2.4 Protein Immobilization on Surfaces
2.5 Carbohydrate Immobilization
2.6 Immobilization of Cells on Surfaces
2.7 Conclusions
3 Surfaces and Substrates Alvaro Carrillo, Kunal V. Gujraty, Ravi S. Kane
3.1 Introduction
3.2 DNAMicroarrays
3.3 ProteinMicroarrays
3.4 Conclusion
4 Reagent Jetting Based Deposition Technologies for Array Construction Mitchel J. Doktycz
4.1 Introduction
4.2 Reagent Jetting–TechnologyOverview
4.3 Thermal Jet BasedDispensing
4.4 PiezoJet BasedDispensing
4.5 SolenoidJet BasedDispensing
5 Manufacturing of 2-D Arrays by Pin-printing Technologies Uwe R. M¨uller, Roeland Papen
5.1 Introduction
5.2 Definitionof ‘Contact’ Pin–Printing
5.3 Overviewof Different PinTechnologies
5.4 Other SystemComponents andEnvironmental Factors
5.5 Pin Printing Process
5.6 Example of a High Throughput Pin–Printing System for Manufacturing of 2D Arrays – the Corning GENII System
5.7 Conclusion
6 Nanoarrays Dan V. Nicolau, Linnette Demers, David S. Ginger
6.1 Introduction
6.1 Introduction
6.2 PassiveNano–scale Arrays
6.3 Computational Nanoarrays
6.4 Dynamic Nanoarrays
6.5 Conclusion
7 The Use of Microfluidic Techniques in Microarray Applications Piotr Grodzinski, Robin H. Liu, Ralf Lenigk, Yingjie Liu
7.1 Introduction
7.2 Biochannel HybridizationArrays
7.3 Chips with Cavitation Microstreaming Mixers –Kinetics Studies
7.4 Integrated Microfluidic Reactors for DNAAmplificationandHybridization
7.5 SummaryandConclusions
8 Labels and Detection Methods James J. Storhoff, Sudhakar S. Marla, Viswanadham Garimella, Chad A. Mirkin
8.1 Introduction
8.1 Introduction
8.2 Fluorophore Labelling and Detection Methods
8.3 Enhanced Fluorescence-Based Assays
8.4 Phosphor Reporters
8.5 Electrochemical Detection
8.6 Metal Nanoparticle Labels and Metal Thin Films for Microarrays
8.7 Conclusions
9 Marker-free Detection on Microarrays Matthias Vaupel, Andreas Eing, Karl-Otto Greulich, Jan Roegener, Peter Schellenberg, Hans Martin. Striebel, Heinrich F. Arlinghaus
9.1 Introduction
9.2 Imaging Ellipsometry andImagingSurfacePlasmonResonanceonBiochips
9.3 Intrinsic UV Fluorescence for Chip Analysis of RareProteins
9.4 Genetic Diagnostics with Unlabelled DNA
Part II DNA Microarrays
10 Analysis of DNA Sequence Variation in the Microarray Format Ulrika Liljedahl, Mona Fredriksson, Ann-Christine Syv¨anen
10.1 Introduction
10.2 Principles of Genotyping
10.3 PerformingtheAssays inPractice
10.4 Conclusion
11 High Sensitivity Expression Profiling Ramesh Ramakrishnan, Paul Bao, Uwe R. M¨uller
11.1 Introduction
11.2 Oligonucleotide Expression Arrays
11.3 cDNA-based Expression Arrays
11.4 Appendix
12 Applications of Matrix-CGH (Array-CGH) for Genomic Research and Clinical Diagnostics Carsten Schwaenena, Michelle Nesslinga, Bernhard Radlwimmera, Swen Wessendorf, Peter Lichtera
12.1Introduction
12.1Introduction
12.2Technical Aspects
12.3Applications
13 Analysis of Gene Regulatory Circuits Zirong Li
13.1 Introduction
13.2 An Experimental Protocol
for GenomeWideLocationAnalysis
for GenomeWideLocationAnalysis
13.3 Example: Identifying the Target Genes of Human E2F4
13.4 Summary
Part III Protein Microarrays
14 Protein, Antibody and Small Molecule Microarrays Hendrik Weiner, J¨orn Gl¨okler, Claus Hultschig, Konrad B¨ussow, Gerald Walter
14.1 Introduction
14.2 ProteinMicroarrays
14.3 AntibodyMicroarrays
14.4 PeptideandOther SyntheticArrays
15 Photoaptamer Arrays for Proteomics Applications Drew Smith, Chad Greef
15.1 Introduction
15.2 Overview of Photoaptamer Discovery and High Throughput Production
15.3 Using Photoaptamer Microarrays
15.4 Discussion
16 Biological Membrane Microarrays Ye Fang, Anthony G. Frutos, Yulong Hong, Joydeep Lahiri
16.1 Introduction
16.2 Biospecific Binding Studies Using Membrane Microarrays
16.3 Conclusions
Part IV Cell & Tissue Microarrays
17 Use of Reporter Systems for Reverse Transfection Cell Arrays Brian L. Webb
17.1 Introduction
17.2 Reporter Systems for ReverseTransfectio
17.3 Reagents andProtocols
18 Whole Cell Microarrays Ravi Kapur
18.1 Introduction
18.2 The Need
18.3 The Solution
18.4 Challenges andOpportunities for Cellular Micrroarrays
19 Tissue Microarrays for Miniaturized High-Throughput Molecular Profiling of Tumors Ronald Simon, Martina Mirlacher, Guido Sauter
19.1 Introduction
19.2 The TMATechnology
19.3 The Representativity Issue
19.4 TMAApplications
19.5 FutureDirections
19.6 Protocol
20 Application of Microarray Technologies for Translational Genomics Spyro Mousses, Natasha Caplen, Mark Basik, Anne Kallioniemi, Olli Kallioniemi
20.1 Introduction
20.2 High Throughput Clinical Target Validation Using Tissu Microarrays
20.3 Examples of Studies Integrating DNA and Tissue Microarray Technologies for the Rapid Clinical Translation of GenomicDiscoveries
20.4 High Throughput Characterization of GeneFunctionUsingLiveCell Microarrays
20.5 Conclusion
20.5 Conclusion